Valproic Acid

Drug Status in USA : Approved
Drug Status in Canada : Approved

pronunciation

pronounced as (val proe' ik)

Why is this medication prescribed?

Valproic acid is used alone or with other medications to treat certain types of seizures. Valproic acid is also used to treat mania (episodes of frenzied, abnormally excited mood) in people with bipolar disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). It is also used to prevent migraine headaches, but not to relieve headaches that have already begun. Valproic acid is in a class of medications called anticonvulsants. It works by increasing the amount of a certain natural substance in the brain.


How should this medicine be used?

Valproic acid comes as a capsule, an extended-release (long-acting) tablet, a delayed-release ( releases the medication in the intestine to prevent damage to the stomach) tablet, a sprinkle capsule (capsule that contains small beads of medication that can be sprinkled on food), and a syrup (liquid) to take by mouth. The syrup, capsules, delayed-release tablets, and sprinkle capsules are usually taken two or more times daily. The extended-release tablets are usually taken once a day. Take valproic acid at around the same time(s) every day. Take valproic acid with food to help prevent the medication from upsetting your stomach. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take valproic acid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the regular capsules, delayed-release capsule, and extended-release tablets whole; do not split, chew, or crush them.

You can swallow the sprinkle capsules whole, or you can open the capsules and sprinkle the beads they contain on a teaspoonful of soft food, such as applesauce or pudding. Swallow the mixture of food and medication beads right after you prepare it. Be careful not to chew the beads. Do not store unused mixtures of food and medication.

Do not mix the syrup into any carbonated drink.

Your doctor may start you on a low dose of valproic acid and gradually increase your dose.

Valproic acid may help to control your condition but will not cure it. Continue to take valproic acid even if you feel well. Do not stop taking valproic acid without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking valproic acid, you may experience a severe, long-lasting and possibly life-threatening seizure. Your doctor will probably decrease your dose gradually.


What are the precautions to be followed?

Before taking valproic acid,
  • tell your doctor and pharmacist if you are allergic to valproic acid, any other medications, or any of the ingredients in the type of valproic acid that has been prescribed for you. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acyclovir (Zovirax); anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants ('mood elevators') such as amitriptyline (Elavil) and nortriptyline (Pamelor); aspirin; clonazepam (Klonopin); diazepam (Valium); doripenem (Doribax); ertapenem (Invanz); imipenem and cilastatin (Primaxin); medications for anxiety or mental illness; other medications for seizures such as carbamazepine (Tegretol), ethosuximide (Zarontin), felbamate (Felbatol), lamotrigine (Lamictal), mephobarbital (Mebaral), phenobarbital, phenytoin (Dilantin), primidone (Mysoline), and topiramate (Topamax); meropenem (Merrem); rifampin (Rifadin); sedatives; sleeping pills; tolbutamide; tranquilizers;and zidovudine (Retrovir). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had episodes of confusion and loss of ability to think and understand, especially during pregnancy or childbirth; coma (loss of consciousness for a period of time); difficulty coordinating your movements; human immunodeficiency virus (HIV); or cytomegalovirus (CMV; a virus that can cause symptoms in people who have weak immune systems).
  • tell your doctor if you are breast feeding.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking valproic acid.
  • you should know that valproic acid may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
  • remember that alcohol can add to the drowsiness caused by this medication.
  • you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking valproic acid for the treatment of epilepsy, mental illness, or other conditions. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants such as valproic acid to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as one week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as valproic acid, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; withdrawing from friends and family; preoccupation with death and dying; giving away prized possessions; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

What are possible side effects of this medication ?

Valproic acid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • drowsiness
  • dizziness
  • headache
  • diarrhea
  • constipation
  • changes in appetite
  • weight changes
  • back pain
  • agitation
  • mood swings
  • abnormal thinking
  • uncontrollable shaking of a part of the body
  • loss of coordination
  • uncontrollable movements of the eyes
  • blurred or double vision
  • ringing in the ears
  • hair loss
Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately:
  • unusual bruising or bleeding
  • tiny purple or red spots on the skin
  • fever
  • blisters or rash
  • bruising
  • hives
  • difficulty breathing or swallowing
  • confusion
  • tiredness
  • vomiting
  • drop in body temperature
  • weakness in the joints

Valproic acid may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.


How to store the medication and dispose it of after its use later?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.


Drug Category/Class

  • Enzyme Inhibitors
  • Anticonvulsants
  • Antimanic Agents
  • GABA Agents
  • Nervous System
  • Antiepileptics
  • Fatty Acid Derivatives
  • Cytochrome P-450 CYP1A2 Inhibitors
  • Cytochrome P-450 CYP2C9 Inhibitors
  • Cytochrome P-450 CYP1A2 Inducers
  • Cytochrome P-450 CYP2C8 Inhibitors
  • Cytochrome P-450 CYP2C9 Inducers
  • Cytochrome P-450 CYP2C19 Inducers
  • Cytochrome P-450 CYP2C8 Inducers
  • Cytochrome P-450 C
Prescribed For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to ...
Weight :144.2114
Structure Valproic Acid
Generic Drug Valproic Acid prescribed For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to ...
Formula

C8H16O2

Valproic Acid has 14 Brands listed


Develpin ER (250 mg)Develpin ER (500 mg)
Devot XL (250 mg)Devot XL (500 mg)
Dicorate ER (125 mg)Discern (125 mg)
Divuna ER (1000 mg)Divuna ER (250 mg)
Divuna ER (500 mg)Epsoval XR (500 mg)
Valcot CR (200 mg)Valcot CR (300 mg)
Valcot CR (500 mg)Valporl CR (200 mg)

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