Drug Status in USA : Approved Drug Status in Canada : Approved
pronunciation
pronounced as (proe pa feen' one)
Why is this medication prescribed?
Propafenone is used to treat arrhythmia (irregular heartbeat) and to maintain a normal heart rate. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
How should this medicine be used?
Propafenone comes as a tablet and an extended-release (long-acting) capsule to take by mouth. The tablet is usually taken three times a day, once every 8 hours. The extended-release capsule is usually taken two times a day, once every 12 hours, with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take propafenone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole; do not crush or open the capsules or divide the contents of a capsule into more than one dose.
You may begin taking propafenone in a hospital so that your doctor can monitor you carefully as your body gets used to the medication. Your doctor may start you on a low dose of propafenone and gradually increase your dose, not more often than once every 5 days.
Propafenone may control your irregular heartbeat, but will not cure it. Continue to take propafenone even if you feel well. Do not stop taking propafenone without talking to your doctor. Your heartbeat may become irregular if you suddenly stop taking propafenone.
What are the precautions to be followed?
Before taking propafenone,
tell your doctor and pharmacist if you are allergic to propafenone, any other medications, or any of the ingredients in propafenone tablets or extended-release capsules. Ask your doctor or pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); certain antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin, in Prevpac), and erythromycin (E.E.S., others);antihistamines; beta-blockers such as atenolol (Tenormin), carteolol (Cartrol), labetalol (Normodyne, Trandate), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), and timolol (Blocadren); certain antidepressants such as desipramine (Norpramin) and imipramine (Tofranil);cimetidine (Tagamet); cisapride (Propulsid) (not available in the U.S.); digoxin (Lanoxin); haloperidol (Haldol); ketoconazole (Nizoral); lidocaine; medications for irregular heartbeat such as amiodarone (Cordarone, Pacerone), bepredil (not available in the U.S.), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide, and quinidine (Quinaglute, others). medications for mental illness and nausea; orlistat (Alli, Xenical); ritonavir (Norvir);rifampin (Rifadin, Rimactane); saquinavir (Invirase); selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem, in Symbyax), paroxetine (Paxil, Pexeva) and sertraline (Zoloft); and venlafaxine (Effexor).
tell your doctor if you have excessive diarrhea, sweating, vomiting, loss of appetite, or decreased thirst and if you have or have ever had a slow heartbeat; low blood pressure; low or high levels of sodium, potassium, chloride, or bicarbonate in your blood; heart failure; or asthma or any other condition that causes your airways to become narrow. Your doctor may tell you not to take propafenone.
in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had a pacemaker; myasthenia gravis (a disorder of the nervous system that causes muscle weakness),or liver or kidney disease,
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking propafenone, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking propafenone.
you should know that this medication may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how it affects you.
tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.
What are possible side effects of this medication ?
Propafenone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
dizziness
dry mouth
headache
nausea
vomiting
diarrhea
constipation
loss of appetite
unusual taste in the mouth
gas
tiredness
anxiety
blurred vision
uncontrollable shaking of a part of the body
difficulty falling asleep or staying asleep
difficulty with coordination
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
difficulty breathing
wheezing
chest pain
new or worsening irregular heartbeat
slow, fast, or pounding heartbeat
swelling of the hands, feet, ankles, or lower legs
sudden, unexplained weight gain
fainting
skin rash
unexplained fever, chills, weakness, or sore throat
How to store the medication and dispose it of after its use later?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Drug Category/Class
Anti-Arrhythmia Agents
Voltage-Gated Sodium Channel Blockers
Antiarrhythmics, Class Ic
Antiarrhythmics, Class I and Iii
Cardiac Therapy
Antiarrythmics, Class I and Iii
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 CYP1A2 Inducers
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C9 Inducers
Cytochrome P-450 CYP2C8 Inhibitors
Cytochrome P-450 CYP2C8 Inducers
Card
Prescribed
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