Pitavastatin is used together with diet, weight-loss, and exercise to reduce the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol'). Pitavastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with pitavastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.
How should this medicine be used?
Pitavastatin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take pitavastatin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pitavastatin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor may start you on a low dose of pitavastatin and gradually increase your dose, not more than once every 4 weeks.
Continue to take pitavastatin even if you feel well. Do not stop taking pitavastatin without talking to your doctor.
What are the precautions to be followed?
Before taking pitavastatin,
tell your doctor and pharmacist if you are allergic to pitavastatin, any other medications, or any of the ingredients in pitavastatin tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking cyclosporine (Gengraf, Neoral, Sandimmune). Your doctor will probably tell you not to take pitavastatin if you are taking this medication.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: erythromycin (E.E.S., E-Mycin, Erythrocin); other cholesterol-lowering medications such as fenofibrate (Tricor), gemfibrozil (Lopid), and niacin (nicotinic acid, Niacor, Niaspan); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); ritonavir (Norvir) taken with atazanavir (Reyataz); or warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with pitavastatin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor if you have liver disease. Your doctor will order laboratory tests to see how well your liver is working even if you do not think you have liver disease. Your doctor will probably tell you not to take pitavastatin if you have liver disease or if the tests show that you may be developing liver disease.
tell your doctor if you drink large amounts of alcohol, if you are 65 years of age or older, if you have ever had liver disease, or if you have or have ever had seizures, muscle aches or weakness, low blood pressure, or thyroid or kidney disease.
tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking pitavastatin. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking pitavastatin, stop taking pitavastatin and call your doctor immediately. Pitavastatin may harm the fetus.
do not breastfeed while you are taking this medication.
if you are having surgery, tell the doctor that you are taking pitavastatin. If you are hospitalized due to serious injury or infection, tell the doctor treating you that you are taking pitavastatin.
ask your doctor about the safe use of alcoholic beverages while you are taking pitavastatin. Alcohol can increase the risk of serious side effects.
What are possible side effects of this medication ?
Pitavastatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
back pain
constipation
diarrhea
memory loss or forgetfulness
confusion
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical help:
muscle pain, tenderness, or weakness
fever
nausea
extreme tiredness
unusual bleeding or bruising
lack of energy
weakness
loss of appetite
pain in the upper right part of the stomach
yellowing of the skin or eyes
dark urine
flu-like symptoms
rash
itching
hives
Pitavastatin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
How to store the medication and dispose it of after its use later?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Drug Category/Class
Hypolipidemic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
HMG CoA Reductase Inhibitors
Lipid Modifying Agents, Plain
Lipid Modifying Agents
Cytochrome P-450 CYP2C8 Inhibitors
Cytochrome P-450 CYP2C8 Inducers
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C9 Inducers
Cardiovascular System
HMG CoA reductase inhibitors
Prescribed
Pitavastatin is used to lower serum levels of total cholesterol, LDL-C, apolipoprotein B, and triglycerides, and raise levels of HDL-C for the trea...