Doxazosin

Drug Status in USA : Approved
Drug Status in Canada : Approved

pronunciation

pronounced as (dox ay' zoe sin)

Why is this medication prescribed?

Doxazosin is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia or BPH), which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. It is also used alone or in combination with other medications to treat high blood pressure. Doxazosin is in a class of medications called alpha-blockers. It relieves the symptoms of BPH by relaxing the muscles of the bladder and prostate. It lowers blood pressure by relaxing the blood vessels so that blood can flow more easily through the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.


How should this medicine be used?

Doxazosin comes as a tablet and an extended-release tablet to take by mouth. The doxazosin tablet is usually taken with or without food once a day in the morning or in the evening. Doxazosin extended-release tablet is usually taken once a day with breakfast. Takedoxazosin around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take doxazosin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release tablets whole; do not split, chew, or crush them.

Your doctor will start you on a low dose of doxazosin and gradually increase your dose, not more than once every 1 to 2 weeks. If you stop taking doxazosin for a few days or longer, call your doctor. Your doctor will have to start you again on the lowest dose of doxazosin and gradually increase your dose.

Doxazosin controls high blood pressure and the symptoms of BPH but does not cure them. It may take a few weeks before you feel the full benefit of doxazosin. Continue to take doxazosin even if you feel well. Do not stop taking doxazosin without talking to your doctor.


What are the precautions to be followed?

Before taking doxazosin,
  • tell your doctor and pharmacist if you are allergic to doxazosin, prazosin (Minipress), terazosin, any other medications, or any ingredients in doxazosin tablets or extended-release tablets. Ask your pharmacist for a list of the ingredients..
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; clarithromycin (Biaxin, in Prevpac); ipratropium (Atrovent, in Combivent); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); medications for erectile dysfunction (ED) such as sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), or vardenafil (Levitra, Staxyn); medications for high blood pressure; medications for HIV/AIDS including atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), or saquinavir (Invirase); medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems; nefazodone; telithromycin (Ketek); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have angina (chest pain); low blood pressure; if you have ever had low blood pressure after taking a medication; or if you have or have ever had prostate cancer, or liver disease. If you are taking the extended-release tablet, tell you doctor if you have constipation, short bowel syndrome (a condition where more than half of the small intestine has been removed by surgery or damaged by disease), or narrowing or a blockage of the intestines.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking doxazosin, call your doctor.
  • talk to your doctor about the risks and benefits of taking doxazosin if you are 65 years of age or older. Older adults should not usually take doxazosin because it is not as safe as other medications that can be used to treat the same conditions.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking doxazosin. If you need to have eye surgery at any time during or after your treatment, be sure to tell your doctor that you are taking or have taken doxazosin.
  • you should know that doxazosin may make you drowsy or dizzy. Do not drive a car, operate machinery, or perform dangerous tasks for 24 hours after the first time you take doxazosin or after your dose is increased.
  • you should know that doxazosin may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking doxazosin, when your dose is increased, or if your treatment has been stopped for more than a few days. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. If you experience these symptoms, sit or lie down. If these symptoms do not improve, call your doctor.

What are possible side effects of this medication ?

Doxazosin may cause side effects. Tell your doctor if any of these symptoms or those listed in the SPECIAL PRECAUTIONS section are severe or do not go away:
  • headache
  • tiredness
  • swelling of the hands, feet, ankles, or lower legs
  • shortness of breath
  • weight gain
  • muscle or joint pain or weakness
  • abnormal vision
  • runny nose
  • decreased sexual ability
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or seek emergency medical treatment:
  • rapid, pounding, or irregular heartbeat
  • chest pain
  • shortness of breath
  • hives
  • painful erection of the penis that lasts for hours

Doxazosin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.


How to store the medication and dispose it of after its use later?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.


Drug Category/Class

  • Antihypertensive Agents
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Antiadrenergic Agents, Peripherally Acting
  • Cytochrome P-450 CYP2C19 Inducers
  • CYP2D6 Inducers
  • CYP2D6 Inducers (strong)
  • Cardiovascular System
  • Alpha-adrenoreceptor antagonists
Prescribed For treatment and management of mild to moderate hypertension and urinary obstruction symptoms caused by BPH.
Weight :451.4751
Structure Doxazosin
Generic Drug Doxazosin prescribed For treatment and management of mild to moderate hypertension and urinary obstruction symptoms caused by BPH.
Formula

C23H25N5O5

Doxazosin has 12 Brands listed


Alfazosin (1 mg)Alfazosin (2 mg)
Doxacard (1 mg)Doxacard (2 mg)
Doxacard (4 mg)Doxapress (1 mg)
Doxapress (2 mg)Duracard (1 mg)
Duracard (2 mg)Duracard (4 mg)
Duraten (1 mg)Duraten (2 mg)

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