Drug Status in USA : Approved Drug Status in Canada : Approved
pronunciation
pronounced as (dye sul' fi ram)
Why is this medication prescribed?
Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. These effects begin about 10 minutes after alcohol enters the body and last for 1 hour or more. Disulfiram is not a cure for alcoholism, but discourages drinking.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Disulfiram comes in tablets to take by mouth. It should be taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take disulfiram exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you cannot swallow the tablets, crush them and mix the medication with water, coffee, tea, milk, soft drink, or fruit juice.
What are the precautions to be followed?
Before taking disulfiram,
tell your doctor and pharmacist if you are allergic to disulfiram or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially amitriptyline (Elavil), anticoagulants ('blood thinners') such as warfarin (Coumadin), isoniazid, metronidazole (Flagyl), phenytoin (Dilantin), any nonprescription drugs that might contain alcohol, and vitamins.
tell your doctor if you have or have ever had diabetes, thyroid disease, epilepsy, brain damage, or kidney or liver disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking disulfiram, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking disulfiram.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
What are possible side effects of this medication ?
Disulfiram may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
skin rash
acne
mild headache
drowsiness
tiredness
impotence
metallic taste or garlic-like taste in the mouth
If you experience any of the following symptoms, call your doctor immediately:
excessive tiredness
weakness
lack of energy
loss of appetitie
upset stomach
vomiting
yellowness of the skin or eyes
dark urine
How to store the medication and dispose it of after its use later?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Drug Category/Class
Enzyme Inhibitors
Alcohol Deterrents
Drugs Used in Addictive Disorders
Ectoparasiticides, Incl. Scabicides
Ectoparasiticides, Incl. Scabicides, Insecticides and Repellents
Drugs Used in Alcohol Dependence
Sulfur Containing Products
Acetaldehyde Dehydrogenase Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C9 Inducers
CYP2E1 Inhibitors
CYP2E1 Inducers
CYP2
Prescribed
For the treatment and management of chronic alcoholism