Dactinomycin (Actinomycin D)

Indication : Why is this medication prescribed?

Wilms tumour, rhabdomyosarcoma, carcinoma of testis and uterus.

Contraindication: What are the special precautions to be followed?

Under following conditions, use of this medication is inadvisable. Its use should be withhold as it would cause harm to the patient
Infection with chicken pox or herpes zoster. Hypersensitivity. Contraindicated during pregnancy and lactation.

Other Precaution to be observed while taking this medication

Exercise caution when administering within two months of irradiation for the treatment of right sided wilms tumour. Discontinue the administration of drug if stomatitis, diarrhoea or severe hemopoietic depression results.

What are possible side effects of this medication ?

Dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, anorexia, nausea, vomiting, abdominal pain, diarrhoea, GIT ulceration, liver toxicity including ascites, hepatomegaly, hepatitis, liver function test abnormalities, anaemia, agranulocytosis, leukopenia, thrombopenia, pancytopenia, reticulopenia, alopecia, skin eruptions, acne, flare-up of erythema or increased pigmentation of previously irradiated skin. Malaise, fatique, lethargy, fever, myalgia, proctitis and hypocalcaemia.

Drug Category/Class

Dactinomycin (actinomycin D) has 6 Brands listed


Actinocin (500 mcg)Cosmegen (500 mcg)
Dacilon (500 mcg)Dacmozen (500 mcg)
Dactino (500 mcg)Dactinoget

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